Suggestions(1)
Exact(1)
Although our primary interest here was in the results of the pyramid analysis of the drug-specific component, the method can be applied to the analysis of general platinum sensitivity including cellular proliferation as well.
Similar(59)
To compare the performance of our integrative pyramid analysis to that of traditional GWAS, we compared the p-value distribution between these analytic approaches.
The (potentially arbitrary) threshold chosen at each stage of the pyramid analysis may of course yield results that are not overall significant; furthermore, the filtering steps (stage 1-5) were done on the same set of samples as those on which the test (at the final stage) for SNP association was done.
To evaluate the performance of the pyramid analysis, we compared the distribution of p-values identified through traditional GWAS and that obtained from our pyramid analysis.
Importantly, our permutation-based method accounts for the potentially arbitrary threshold used at each stage of the pyramid analysis.
These results demonstrate the substantial gain in power from an application of the pyramid analysis, at least for some traits, despite the small sample size.
Through our pyramid analysis, we discovered a set of SNPs, miRNAs, and genes which potentially comprise a functionally important regulatory pathway in cellular sensitivity to the platinating agents.
(6) Y i = δ 0 + δ 1 S ki + W i θ + ϵ * * * * * i with ϵ * * * * * i ~ N 0, σ * * * * * 2 genetic association testing In our particular implementation of the pyramid analysis, we chose p < 0.05 in stages 1 and 2 to select the trait-associated genes and miRNAs.
The pyramid analysis was performed using carboplatin and cisplatin DSPs instead of IC50s this time.
The GL filters from the family of orthogonal functions, satisfying the wavelet admissibility condition required for multi-resolution wavelet pyramid analysis, are used.
The pyramid analysis is a six-stage analytic framework.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com