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Fast-food nation was invented in the eighteen-thirties, and Captain Hall's puzzled observation that in America the word "improvement" seemed to mean "an augmentation in the number of houses and people and above all in the amount of cleared land" has not lost any of its validity with the passing of a hundred and seventy-odd years.
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But Anderson was still puzzled by her observation that the rash came out only at school and went away "10 or 15 minutes after the girls left school".
Scientists have long puzzled over the observation that drug-resistant malaria arises more often in southeast Asia than in Africa, which has the world's highest prevalence of the disease.
For many years, physiologists have puzzled over the observation that, during maximum aerobic exercise, high-altitude natives generate lower-than-expected amounts of lactate; the higher the altitude, the lower the postexercise blood lactate peak.
However, the shrinkage of this tumor during observation puzzled us.
Therefore, we were puzzled by the observation that for signaling by female germ-line cells, epsin is needed, but clathrin is dispensable [40].
We were puzzled by the observation that synaptic depression was facilitated both during the training and test phases of OR.
We were also puzzled by the observation that EGFP-Rab26, unlike FLAG-Rab26, does not readily localize with LC3.
In addition, some investigators have puzzled over the observation that the common genetic variants identified by GWAS explain little of the familial clustering of these diseases.
Puzzled by the observation that APS attenuates IL-1β-mediated NF-κB activation (Fig. 2c e) and NF-κB-dependent gene expression but does neither suppresses IL-6 nor IL-8 secretion we wondered as to whether this antioxidant may alter the activation of MAPKs in SZ95 sebocytes.
We were initially puzzled by our observation that cases with signs of severe or complicated disease were more likely to be taken to traditional healers rather than other sources of care where modern Western style clinical diagnostic methods and treatments were available (Table 6).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com