These putative benefits hardly seem worth it.
And the irony is that for all that downside, the putative upside might not be worth it.
It is also worth noting that putative MAP3K1 gain-of-function during XY female development might be interpreted as implying a positive role for MAP3K1 in ovary development itself.
Two genes for putative Rab proteins are also worth mentioning, rabR (DDB0168590) and rabQ (DDB0190014), which are up and down, respectively (see Additional File 1).
In fact, among the identified 35 CNVRs, 14 were specific to the high fertility animals, while 19 CNVRs were specific to the low fertility group, thus worth investigating their putative roles in fertility.
It is worth noting that a putative estrogen-responsive element (ERE) has been identified in the promoter region of the FasL gene [ 52], suggesting direct estrogen effects on FasL expression.
Also worth noting are two putative MrpC binding sites in the vicinity of epsL (MXAN_7437, aka czc3A; Additional file 6), a gene noted above as down-regulated during development in microarray experiments [ 58, 59] (Additional file 7, column B).
There were no cries then for the O'Brien horse to lose because it was 'boring', no disappointment at being deprived of Dettori's leap, no sense of envious exclusion just because Galileo was worth, on that day, a putative £100m.
It is worth to note that a putative but not significant QTL located on chromosome 3 (with LOD score of 1.8, marker position c3_15714, 41 cM) was detected during the QTL mapping (Figure S4).
Nevertheless, such cases are worth examining in search of putative TAS with novel molecular mechanisms that might merit experimental validation.
Although our findings do not allow further speculation due to modest changes in MMP expression, the putative functions of nuclear MMP's are worth further studies considering the process of cervical carcinogenesis.
