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A second melanoma susceptibility gene, CDK4, has been identified in five families to date worldwide [ 14], but in >50% of all families with pathologically confirmed invasive cutaneous melanomas no putative responsible gene has yet been identified.
Our technique is also extendable to include any types of biomarkers, including alternatively spliced isoforms and protein expression or post-translation modification data, shedding further light on putative responsible pathways.
Several painful cervical and thoracic disorders are related to trigger points in the trapezius muscle, and misdiagnosis of these conditions is common when the putative responsible MTrPs are not adequately evaluated [ 6].
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The same analysis in leaves revealed that genes encoding putative enzymes responsible for production of jasmonates and other volatile compounds were up-regulated.
SSR markers were applied based on F-statistics from single-locus ANOVA results to narrow down the putative location responsible for the floury endosperm characteristics (see Table 4; ANOVA).
Nine polymorphic SSR markers were applied to narrow down the putative location responsible for the floury endosperm characteristics by increasing the marker density of chromosome 5 (Table 4; Locus, Ap = 2).
Due to the absence of information on a putative receptor responsible for this activity, classical quantitative structure activity relationships (QSAR) and comparative molecular field analysis (CoMFA) have been applied.
Conceiving of malignancy as a solid phase coagulopathy may facilitate development of effective but non-toxic cancer treatments and encourage inquiry into the putative 'injury' responsible for both coagulation activation and carcinogenesis.
After conducting a first round of association analyses over well-defined 6 anchor markers (application: Ap = 1), an additional 9 SSR markers (Ap = 2) were applied to narrow down the putative location responsible for the floury endosperm characteristics on chromosome 5.
The putative masses responsible for the metabolic differentiation were used to make queries in the KEGG database (Kyoto Encyclopedia of Genes and Genomes) through the MassTRIX software [15] including Homo sapiens and Bacteroides vulgatus as reference species.
Therefore it appears that the GSA recognised by the antibodies we have described are distinct from the putative ligands responsible for sequestration of immature gametocytes during their development [20], [34].
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