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This is surely a case of "solutions" that have sadly been much worse than the putative problem they were meant to solve.
If we are not prepared to endorse four dimensionalism, it remains to be seen how the putative problem about Cup and Tcup's identity through time can be reformulated so that it is no longer a problem about identity through time.
It is "damaging to the blind not only because it focused attention on a putative problem that did not exist but also [because] it would present the capacity of the blind in a false and misleading manner," said Maurer, who is blind.
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Microorganisms are believed to be a promising feedstock for the production of many by-products (lactic acid, single cell proteins, bioethanol, polyunsaturated fatty acids) that can resolve the putative problems and cover a wide range of industrial applications.
To circumvent putative problems with redundancy between MEF2B and other MEF2 proteins, generation of double or multiple MEF2 knockouts is especially interesting and would provide a deeper comprehension of the different and/or overlapping functional roles of the four MEF2 members in vertebrates.
I would encourage the authors to remove immediately the baseless claims about putative problems with the PAXgene reagents or protocol.
The primers were designed relatively far away from the polymorphic region to alleviate putative problems related to allele specificity during PCR amplification.
The title of the manuscript has also been changed to clarify the message of the "I would encourage the authors to remove immediately the baseless claims about putative problems with the PAXgene reagents or protocol.
Accordingly, they attributed this lack of resolution to some putative problems, namely, a persistent long-branch-attraction (LBA) artefact, a bias of amino-acid or nucleotide composition, a divergence between the variants of RP genes and finally the sampling of a too limited set of taxa.
Crudely put, Wittgenstein held that all putative philosophical problems were merely puzzles caused by linguistic confusion.
The current data extend these findings to alcohol dependence as well as a putative behavioural addiction (problem gambling), which supports the role of reflection impulsivity as a potential vulnerability marker in the addictions.
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