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Chief executives and corporate directors should "claw back" pay when putative gains turn into losses.
But back in 1993, Jonathan Cohn, writing in The American Prospect, explained that "under Reagan and Bush, the ranks of public officials necessary to supervise contractors have been so thinned that the putative gains of contracting out have evaporated.
Do the putative gains in convenience, safety, and fuel-economy from a particular bike lane outweigh the costs to motorists (and other parties, such as taxpayers and local businesses)?
Our method of analysis necessitates that all the genes we identify as putative gains by HGT result in gene family expansion rather than in the acquisition of new biochemical functions.
As parallel losses in two lineages are counted as gains in the third lineage with this outgroup-based approach (supplementary fig. S2 a and b, Supplementary Material online), it leads to an overestimation of putative gains.
Thus, not all detected putative gains of TFBSs in BY4741 or losses in other strains or species necessarily reflect real changes of TF binding, but might be the consequence of changes in the DNA binding region of specific TFs and compensatory evolution in the TFBS.
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In same way, the putative gained introns of these two species were mapped to 86 intron-gained genes of Dictyostelium discoideum, which were compared with background sets for GO enrichments.
Progeny from putative gain-of-resistance mutants and "sister" M2 plants (a total of six M2 lines per M1) were inoculated with PXO87 to confirm the mutation.
Three examples regarding the putative gain of multigene clusters are considered in the following sections.
As an example, the putative gain of miR535 binding site was shown in Additional file 7.
Consequently, the mechanism underlying the genetic dominance and the putative gain-of-function underlying the pathology of CMT2B remains unclear.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com