Sentence examples for putative defect from inspiring English sources

The present data also provides an indication of a putative defect in GAG sulfation, which may lead to dramatic biological effects, as exemplified by mutations in PAPSS2, SLC26A2, gPAPP or SUMF1, all causing skeletal dysplasias [41] [44].

To determine which of these mutations were able to compensate for the putative defect in the chimeric GBV-B/HCV genome, we introduced either one or a combination of these nucleotide substitutions into the chimeric GB/IIIHC genome and assessed the infectivity of each corresponding synthetic RNA by intrahepatic inoculation into a GBV-B-naïve tamarin (Fig. 4).

The following text has been added: "A putative defect in regulatory T cells cannot explain the increased CD44 expression on naïve Rasgrp1 Anaef CD4+ cells, because in mixed chimeras bearing many wild-type Foxp3+ cellsells, CD44 expression was still increased on Rasgrp1 Anaef but not on co-resident wild-type CD62L+ FOXP3– CD4+ splenocytes".

A putative defect in regulatory T cells cannot explain the increased CD44 expression on naïve Rasgrp1 Anaef CD4+ cells, because in mixed chimeras bearing many wild-type Foxp3+ cellsells, CD44 expression was still increased on Rasgrp1 Anaef but not on co-resident wild-type CD62L+ FOXP3− CD4+ splenocytes.

In the current study we have screened for functional deficiencies consistent with putative defects of CatSper function in men with normal semen parameters attending for IVF treatment.

Nevertheless, because of the simultaneous accumulation of fat in the liver, visceral depot, and skeletal muscle, we were unable to differentiate the individual effect of each one of these on putative defects in glucose and lipid metabolism.

To assess the putative defects in growth cone anatomy, we first analyzed potential differences in the intracellular localization or quantity of actin and tubulin, two generally utilized markers for initial characterization of the integrity of neuronal projections.

It is possible that the methods employed in this paper are not sensitive enough to detect this type of subtle loading defects, and it is also conceivable that any putative loading defect of condensin or Smc5/6 is restricted to only a few discrete loci as well.

Because ClC-7 is not dependent on Ostm1 to reach the lysosomes in general [10], the function of Ostm1 in our experiments might be to compensate a putative folding defect caused by the G213R mutation.

This putative field defect associated with gene promoter hypermethylation in normal appearing colorectal mucosa has been suggested with respect to the MGMT gene [12], as well as ERα, MYOD, P16 INK4A), MLH1, TIMP3 and DAPK [13].

Persons with the putative immunological defect probably responsible for classic Whipple disease (1 ) have the highest bacterial load in their stools.