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At trial, Microsoft attempted to rebut the presumption of monopoly power with evidence of both putative constraints on its ability to exercise such power and behavior of its own that is supposedly inconsistent with the possession of monopoly power.
There are some unifying themes in these putative constraints on subjective probability.
This lack of correlation can be explained by putative constraints in the evolution in both traits, such as the minimum genome size or the proportional evolution for GS, and the lower responses of FD to selection in self-compatible species, as already discussed.
In a first step, a conceptual framework will be developed which defines and systemizes putative constraints of the genome architecture on somatic cancer evolution.
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This has been suggested for ruminants, due to the high proportion of energetic methane losses in this group [25]; for nonruminant mammals, these losses might become limiting at extrapolated body masses of 100 metric tonnes [26] – a putative constraint that might apply conceptually for the largest dinosaurs [1].
The diversity of futures studies is a permanent memento, reminding us to sound out the possibilities of shaping instead of rashly assuming determinisms and following putative factual constraints which are often only an expression of technocratic thinking or specific interests.
A systems approach of carcinogenesis has been proposed which focuses on putative inner constraints of the genome architecture on lineage selection during somatic cancer evolution.
SubstrateSBS (or inhibitorSBS) was docked with the following binding site putative physicochemical constraints (51): (a) close proximity of the ligand Ser(p) to the kinase Arg, Arg, and Lys at the SBS, and (b) close proximity between the substrateSBS Ser (to be phosphorylated) and the kinase conserved catalytic Asp.
Here, we examined the role of stress-induced trans-generational plasticity in mitigating a putative genetic constraint that may contribute to low-elevation range limits in B. stricta (Siemens et al. 2009).
Substitution of the serine with an alanine at position 1369 (Ala) removes only the side chain terminal hydroxy group that would remove the ability to hydrogen-bond with Gln and reduce a putative structural constraint on the hairpin loop, resulting in the observed increases in MgATPase activity.
Dissection of putative mechanisms mediating constraints exerted by the genome architecture on somatic cancer evolution may provide an algorithm for understanding and predicting as well as modifying somatic cancer evolution in individual patients.
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