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And the launch of too many models at the same time risks pushing margins down.
Demand-driven growth is pushing margins higher.
Looking back over the last 10,000 years of pollen data for the Mediterranean, Guiot found that severe drought has changed vegetated areas in the region by 10%to15%5%—often pushing margins of the land cover in other directions.
Keratinizing type is characterized by large tumor island with variable "pearl" formation pushing margins.
Gas6-positive tumours were associated with pushing margins on histological assessment.
Pushing margins have been found in BRCA1 mutation-positive patients with breast cancer (Lakhani, 1999).
Similar(18)
However in our study peritumoural liver was examined since liver metastases tend to have what is described as a pushing margin rather than an invasive margin.
Colorectal cancers with a pushing margin had a significantly better disease-free survival than the infiltrative margin tumours (log rank P=0.017).
Studies have also shown the pushing margin in primary cancers to have a better prognosis than the infiltrative margin tumours (Jass et al, 1987).
Pushing margin, defined here as a continuous front of cells observed in >50% of the tumour circumference and scored as: (1) yes and (2) no.
Primary CRCs with a pushing margin tended to form capsulated liver metastases (P<0.001) and had a significantly better disease-free survival than the infiltrative margin tumours (log rank P=0.01).
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