Sentence examples for push substrates from inspiring English sources

T6SS genes are believed to be involved in either structural components of the secretory apparatus, secretory products or assisting with protein translocation; for example, providing the energy to push substrates through the channel of the apparatus [ 26].

BGIBMGA009572 was predicted to encode translocase subunit secA, which might play role in pushing substrates forward like a "motor" [ 34].

Molecular dynamics and normal-mode analysis suggest that anticorrelated motions of the catalytic and coenzyme binding domains can push the substrates together, and the V203A substitution could allow the nicotinamide ring to move away from the substrate and diminish the fraction of reactive conformations.

Anticorrelated motions of the catalytic and coenzyme binding domains that are related to the relatively slow global conformational change that accompanies coenzyme binding are suggested to "push" the substrates in the Michaelis complex toward a reactive state, but the contribution to hydride transfer may be modest.

The data also indicate that insulin secretion is a minor energy consuming process in the β-cell, and that the β-cell is different from most cell types in that its metabolic activation appears to be primarily governed by a "push" (fuel substrate driven) process, rather than a "pull" mechanism secondary to enhanced insulin release as well as to Ca2+, cAMP and PKB signaling.

4) Is the β-cell similar or different from most tissues in term of metabolic activation, specifically whether it is primarily governed by a "push" (fuel substrate driven) process, rather than a "pull" mechanism secondary to enhanced activation of its major cellular function.

Importantly, as these conformational changes (of the β8−α8 loop and Arg213) push the substrate deeper into the active site, some rearrangement must be necessary to avoid a steric clash between Lys170 and substrate carbonyl and differentiate this state from the one observed in the K170M DHQ complex structure.

Gudgeons can push sand substrate to customize the cave to their liking ie blocking an end or deepening/filling the cave.

This indicates that, after hydrolysis, gp16 undergoes a further conformational change that produces an external force against the dsDNA and pushes the substrate away from the motor complex by a power stroke.

Another factor governing His 64's position appears to be a steric "push" from the substrate's P1′ side chain (Ser 78′), which is 4.1 Å from His 64 (Cβ−Cβ distance) (34).

We demonstrate that excess substrates will push the enzyme to a less active state.