Instead, they said, push the doses of statins where there is proven evidence.
One likely answer: As they push the doses of existing cholesterol drugs to the limit, they will turn to add-on therapies.
The lack of side effects allowed us to push the dose to an extremely high level that reached the bell-shaped part of the dose curve.
Bromocriptine dominates the literature, yet it has a poor side effect profile both in terms of short-term administration (as shown in several of the trials reviewed here that tried to push the dose to 30 mg/day and beyond) and in terms of longer-term risks of cardiorespiratory fibrosis.
Senator Tom Daschle of South Dakota, the minority leader, said in a statement in response to the speech that "against the advice of Chairman Greenspan and the consensus of economists, the Republican leadership is pushing another dose of a prescription that has already failed".
Overall hypoglycaemia did not differ, but nocturnal hypoglycaemia, though low in frequency, was more frequent with basal insulin, perhaps indicating that in some individuals pushing the dose too hard when short-acting insulin is required can give problems at night.
The first two arrows of Mr. Abe's economic push — a sizable dose of monetary and fiscal stimulus — initially impressed investors, sending the stock market soaring as much as 80 percent in six months.
but rather represent "organ-type" toxicities that are difficult to predict [22] (ii) To push the drug dose up to the MTD might not lead to greater clinical or biological effects since MTA could not exhibit dose dependant toxicity or efficacy profiles [6] [7].
Somatostatin was administered by intravenous push at a dose of 0.25 mg/hour.
Therefore it was analyzed whether calves that were barely able to stand (unable to correct position if pushed) require higher doses of sodium bicarbonate in general, or whether these buffer requirements depend on the quality of the palpebral reflex.
