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65 The tolerability and activity seen with nivolumab in previously-treated NSCLC patients, including 54% of patients with three prior lines of therapy, was notable and served as the basis for pursuing Phase III trials.
Because of the modest survival benefit of 5-FU-based chemoradiotherapy, numerous investigators are pursuing phase I and II trials of radiotherapy with new chemotherapeutic agents such as gemcitabine, paclitaxel, capecitabine, bevacizumab, gefitinib and erlotinib (Blackstock et al, 2003; Okusaka et al, 2004; Rich et al, 2004; Crane et al, 2006; Czito et al, 2006).
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However, we remain cautious on the decision to pursue Phase III development of Varisolve in the absence of a partner.
"If China takes retaliatory action against our farmers or other industries, we will immediately pursue phase three, which is tariffs on approximately $267 billion of additional imports," Trump said in a statement.
A range of motivators pushed transport planners to pursue Phase 3b, including attracting new passengers, value to the economy, reduction of road traffic congestion, regeneration, and improved access to town centres, business districts and labour markets.
If phase determination still proves challenging, it is simple to make a choice and pursue phase goals that make the most sense for the patient.
Accordingly, while we have defined an MTD for this regimen, this lack of long-term PFS, along with the lack of benefit of AHSCT in the randomized trials cited above, have prompted us to defer pursuing a phase II trial of this regimen at this time and further indicates that there are little or no data to support the use of AHSCT in the treatment of ovarian cancer outside of clinical trials.
Cruz said he told the House members that the leadership strategy of pursuing distinct "phases" of legislation was a dead end and that they needed to push for changes in the present bill.
And there is very little pressure for companies (or anyone else) to pursue a phase 3 trial confirming efficacy shown in earlier exploratory trials.
Trial will be pursued in phase III with 2 or 3 arms according to IDMC recommendations.
50 Two MUC1 vaccines, L-BLP25 and TG4010, have shown evidence of activity in clinical trials, and are being pursued in Phase III trials.
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