Since in vivo oxidation of DHA may have adverse effects, particularly in ApoE4 patients, should preclinical and clinical studies be performed to optimize dose and mitigate oxidation before pursuing intervention or prevention trials with DHA?
Hospital physicians also pointed out that they would prefer to pursue intervention through new programmes for hygiene, although they also recognise it to be a challenging method of improvement.
People with hearing loss tend to be influenced by various people in society, including significant others, friends, colleagues, and health professionals, in deciding whether to seek help and to pursue intervention to resolve their difficulties, as seen in patient journey studies.
Furthermore, given that many older adults did not pursue intervention for 8 to 12 years after the first notice of a hearing impairment [ 17], a longer duration of hearing aid use is probably needed to demonstrate any effects of reversal of cognitive decline [ 16].
For instance, if an efficacious intervention does not affect a surrogate this will lead to a false-negative proof-of-concept study result and may lead to abandoning the intervention and not pursuing the intervention in confirmatory studies.
And second, they underscored the importance of pursuing programmatic interventions that can improve both immunization and gender equity.
A prospective study with objective criteria is needed to determine the true efficacy of pursuing further interventions after CE.
