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The DNA-binding transcription factor PAX6 was cloned 25 years ago by multiple teams pursuing identification of human and mouse eye disease causing genes, cloning vertebrate homologues of pattern-forming regulatory genes identified in Drosophila, or abundant eye-specific transcripts.
However, most analysis software are not pursuing identification of multiple true peptides.
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To pursue identification of a distinct marker, this study profiled the secretory proteome in 16 PDAC, 2 carcinoma in situ (CIS) and 7 benign patients using label-free mass spectrometry coupled to 1D-SDS-PAGE and Strong Cation-Exchange Chromatography (SCX).
Through a large interdisciplinary approach the "Tailor Made Fuels from Biomass" (TMFB) cluster of excellence has been pursuing the identification of next generation biofuels.
Anyway, appearance of this fragment in ischemic brain supported the relevance of pursuing the identification of that specific calpain-cleavage site within Kidins220 to develop a neuroprotective strategy.
Consequently, we are pursuing the identification of all soluble hydrolases that use this alternative receptor by means of RNAi and proteomics.
The findings that differentiation is a powerful inhibitor of cancer initiation provide a strong rationale for pursuing the identification of the stem cells susceptible to carcinogenesis and of the genes that control this process.
Ongoing studies are pursuing the identification of the cell of origin as well as genetic and epigenetic changes or alterations in signalling pathways associated with each breast cancer subset.
This study was designed to pursue the identification of optimal restriction enzyme for pulsed-field gel electrophoresis (PFGE) analysis of Candida tropicalis.
Ongoing studies in our laboratory pursue the identification of additional partners of CFTR.
We have pursued the identification of COUP-TFI in vivo direct targets to reveal genes and pathways that are important for inner ear development and functional maturation.
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