A numerical approach pursuing to optimize a long-span bridge needs to explore changes in the deck shape, including structural and aeroelastic responses as design constraints.
In short, there are viable avenues to pursue to optimize the in vivo glycosylation of the aglycone using novel sugar biosynthesis pathways and matching them with different glycosyltransferases. Extracts producing a mixture of glycosylated analogues, including angolosaminyl-6-dEB, angolosaminyl-EB, and possibly mycaminosyl-6dEB, had antibiotic activity.
Several approaches have been pursued in order to optimize the mechanical behavior of CNT fibers, including irradiation-induced covalent cross-linking, reformable or rehealable bonding, and optimized geometrical and structural fiber designs.
One interviewee noted that "We have inadequate precedence in the cell therapeutic space for having set price points and determining reimbursement," a situation that makes it difficult for companies to make strategic decisions about which indications to pursue and how to optimize their operations.
Current work is ongoing to optimize the laser settings and pursue improved designs which will be more sensitive tests of OCT systems than this initial trial.
This is because we mainly try to optimize the detecting efficiency instead of pursuing the highest accuracy.
We decided on pursuing a postmortem study, rather than neuroimaging, in order to optimize the resolution of the gray-white matter transition zone.
Since in vivo oxidation of DHA may have adverse effects, particularly in ApoE4 patients, should preclinical and clinical studies be performed to optimize dose and mitigate oxidation before pursuing intervention or prevention trials with DHA?
Therefore, further studies are necessary to optimize the insonation condition, and future studies should pursue the tradeoff between the efficacy and safety in respect to MB concentration and US intensity.
However, for maximum efficacy, matching that of PA, further studies need to be performed to optimize dose, administration route, and time of inhibitor injection in respect to radiotracer injection and are currently actively pursued.
