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To pursue structure-influenced recognition of protein interactions, two datasets were used: (i) a cumulative dataset of structures of transient protein protein complexes published earlier 27– 29 and (ii) a dataset of domain-centric protein protein interactions from Protein Family Interactions (iPfam) database.
To understand the structural basis for HMW1 glycosylation, we have pursued structure and function studies of HMW1C.
Most screening campaigns produce too many hits to pursue with structure determination or chemical follow-up and the list must be reduced to a small number of high priority compounds.
Whilst the SGC focuses primarily on human targets, we also pursue the structure determination of proteins from parasitic organisms associated with neglected diseases, such as malaria and toxoplasmosis.
Max Perutz decided to pursue the structure of hemoglobin in 1937, at a time when genes were generally thought to be proteins, and when proteins acting as enzymes had only recently been recognized to catalyze chemical reactions in living systems.
Michael Horowitz, another former chief of the public corruption unit in Manhattan, said that it was rare for prosecutors to pursue a structuring charge without a substantive underlying crime like money laundering or drug trafficking.
No other scientists were pursuing the structure with such single-mindedness.
We therefore pursued the structure of the RBD in its unbound form.
4, 5 Perutz, under generous support and advice from William Lawrence Bragg and John Desmond Bernal, 6 nevertheless pursued the structure.
Structures of eukaryotic membrane proteins are actively pursued for structure-based drug development.
KKR had initially considered structuring KFN as a business development company like Apollo Management's Apollo Investment Corporation but chose to pursue the REIT structure to capitalize on the strength in REIT valuations at the time.
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