However, we remain cautious on the decision to pursue Phase III development of Varisolve in the absence of a partner.
A range of motivators pushed transport planners to pursue Phase 3b, including attracting new passengers, value to the economy, reduction of road traffic congestion, regeneration, and improved access to town centres, business districts and labour markets.
If phase determination still proves challenging, it is simple to make a choice and pursue phase goals that make the most sense for the patient.
65 The tolerability and activity seen with nivolumab in previously-treated NSCLC patients, including 54% of patients with three prior lines of therapy, was notable and served as the basis for pursuing Phase III trials.
Because of the modest survival benefit of 5-FU-based chemoradiotherapy, numerous investigators are pursuing phase I and II trials of radiotherapy with new chemotherapeutic agents such as gemcitabine, paclitaxel, capecitabine, bevacizumab, gefitinib and erlotinib (Blackstock et al, 2003; Okusaka et al, 2004; Rich et al, 2004; Crane et al, 2006; Czito et al, 2006).
Mr. Sharon, though, said he would pursue peace in phases, and seek another long-term interim arrangement.
Trial will be pursued in phase III with 2 or 3 arms according to IDMC recommendations.
50 Two MUC1 vaccines, L-BLP25 and TG4010, have shown evidence of activity in clinical trials, and are being pursued in Phase III trials.
103 Given that all the patients in the trial had previously failed tamoxifen therapy and had very few negative side effects from treatment, droloxifene was pursued in Phase II trials.
Despite this, no patient stratification or population enrichment based on histological subtype, IGF-1R tumour expression or circulating fIGF1 levels was pursued in Phase III trials (Jassem et al, 2010).
Combination studies with erbB receptor tyrosine kinase inhibitors are therefore being pursued, including Phase II studies of ZD1839 and anastrazole, and GW572016 and letrozole, in patients that have previously failed aromatase inhibition.
