More importantly, their systematic exclusion from clinical trials meant that we did not know how to design appropriate treatment plans for women, whose different hormones and reproductive system, longer life span, and other medically relevant differences meant that treating them as smallish men for the purposes of dosing drugs and other treatment decisions was not a medically sound strategy.
It was not prospectively designed for the purpose of dose-sparing and was not intended to provide any specific dosing target or recommendations.
For the purpose of dose calculation, the stainless steel cable extended 2 mm from the outer cover on the proximal side of the active source.
17 However, the ulcers were measured every four weeks for the purpose of dose adjustment, and, although this was done by the unblinded nurse, there is no reason for systematic errors (bias) being introduced as the primary outcome measure was time to complete healing as assessed by a blinded assessor.
As discussed below, and in detail by Stern and Smith (2003), the correct value for the purposes of dose reconstruction is the concentration of MeHg + MeHg-derived inorganic Hg.
Although data regarding genetic polymorphisms or serum drug levels are lacking, the present results still suggest that neutropenia can be used as a marker of chemotherapeutic efficacy for the purposes of dose escalation, regardless of its mechanisms.
A new formulation of nevirapine – nevirapine extended-release (XR) – has been developed for the purpose of daily dosing at 400 mg (administered after a 200-mg daily lead-in period).
The purpose of the dose response study was to select a dose, which was not only effective in inhibiting tumour growth but also displayed minimal toxicity in the mice.
However, for clinical purposes, knowledge and use of doses close to the ED95 are more relevant.
