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Additional studies are needed to clarify which other mechanisms are maybe responsible for enhancement of these ipRGC mediated pupil responses occurring with age.
By using the eye-head integrated tracking system, we collected both pupil responses and head positions while participants conducted both process monitoring task and Multi-Attribute Task Battery (MATB-II) tasks.
Since ocular pathologies such as glaucoma cause degeneration of melanopsin RGCs [43] this may alter not only pupil responses [44] but also other non-visual responses to light.
Pupil responses to red light did not correlate to age.
Pupil responses were recorded by video cameras under infrared illumination.
Negative constriction was defined as responses <5% to distinguish evoked pupil responses from random noise.
Similar(16)
The position of the camera is responsible for the particular shape of the pupil response.
In contrast, the smaller phasic pupil response found under high load remained unaffected by luminance.
When controlling for ApoE allele type the odds ratio for pupil response as a risk factor increased to 4. The analysis also found that an exaggerated pupil response was a significant (p = .02) predictor of cognitive decline.
But when he was instructed to try the math problem, his pupil response showed when he was computing.
These results showed that luminance impacts the cognitive pupillary reaction – tonic pupil diameter (phasic pupil response) being modulated under sustained (respectively, transient) cognitive load.
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