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10.7554/eLife.04711.006 Figure 2. Punishment processing by quality.
The first of these is reward and punishment processing and its relation to behavioral conditioning.
This was confirmed by Apostolopoulou et al.: ablating Gr33a-Gal4 positive gustatory sensory neurons reduces feeding-suppression by quinine, but leaves punishment processing unaffected (Apostolopoulou et al., 2014b).
Moreover, it is also important to determine whether the effects of 5-HT are specific to punishment processing or extend into the reward domain.
This is due, in part, to the opposing effects that global depletions of 5-HT appear to have on punishment processing.
Reward and punishment processing are compromised in patients with substance use disorders (SUDs) compared to healthy subjects (De Ruiter et al., 2009; for a review, see Diekhof et al., 2008).
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This provides additional evidence in favour of the involvement of BIS-anxiety in processing punishment risk contingencies: once the punishment was announced as a condition in some of the games, participants with higher levels of BIS-anxiety avoided contributing nothing (made no zero contributions on any trials of the remaining blocks).
These data do not support punishment-processing or prepotent response inhibition accounts of ventrolateral prefrontal cortex function.
We have identified a second main system with reduced cortical connectivity in autism, the ventromedial prefrontal cortex (ORBsupmed), which itself is implicated in emotion and social communication by virtue of its reward and punishment, including face expression, processing (Rolls, 2014).
Unlike some previous adolescent studies, our z-shim procedure [35] allowed good visualization of orbitofrontal regions that are important in processing reward and punishment [18].
Serotonin has been proposed to be involved in processing reward and punishment (Maswood et al., 1998; Daw et al., 2002; Maier and Watkins, 2005; Nakamura et al., 2008; Ranade and Mainen, 2009; Tops et al., 2009; Cools et al., 2011; Amo et al., 2014).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com