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Blocking octopamine/tyramine neurons with TDC2-GAL4 did not cause a significant defect in sucrose reward or shock punishment memory.
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Over the first 4 h following training, relief-memory decays much slower than punishment-memory (figure 1 b).
That is, cold-amnesia typically spares a so-called amnesia-resistant component of reward- and of punishment-memory.
By 24 h after training, however, relief-memory is lost, whereas a third of punishment-memory scores still remain.
In fact, within 75 min punishment-memory has decayed to approximately 50percentnt of the initial score.
Critically, however, punishment-memory remains detectable for at least 24 h (OSS for each retention period: p < 0.05/5 in all cases).
The same treatment reduces punishment-memory scores only to about half (MWU: p < 0.05, U = 54.00, N = 14, 14; OSS: p < 0.05/2 for each group).
In accordance with such rapid temporal decay from 75 min on, retrograde amnesia erases relief-memory but leaves a half of punishment-memory scores intact.
In terms of absolute learning scores (figure 1 b), punishment-memory is obviously much stronger than relief-memory, as has been reported previously [ 2, 3].
During the first 75 min following training, relief-memory is stable, whereas punishment-memory decays to half of the initial score.
Indeed, we confirm that punishment-memory 1 h after training is composed of an amnesia-sensitive component and an amnesia-resistant component (figure 2).
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