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We provide evidence that the cellular function of βA3/A1-crystallin involves its interaction with V-ATPase, the proton pump responsible for acidification of the endolysosomal system.
In addition, GnRH agonists can reduce electrolyte disturbance complications in premenopausal women by enhancing the action of the sodium-potassium ATP-ase pump responsible for shunting sodium outside the cells.
Recently, it has been suggested that NAA may function as a molecular water pump, responsible for the removal of large amounts of water from the human brain.
The efflux pump responsible for the mitoxantrone resistance in these cell lines is as yet unknown.
A new category of enzymes, a "pump" responsible for accumulation of small molecules into the bacteria, was born.
They also reported an interaction between PS1 holoprotein and the V0a1 subunit of the vesicular ATPase, an intracellular proton pump responsible for acidifying autophagosomes and lysosomes.
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Quinolones and betalactamins were recently found in the cerebrospinal fluid of HE patients and it has been shown that the expression of efflux pumps, responsible for drugs passing through the BBB, was altered in animal models of HE.
This verapamil treatment was based on verapamil inhibition of the ion-pumps responsible for Hoechst 33342 dye exclusion, thus enabling the SP cells to be seen [38].
It is well established that MRP7, P-gp and MRP1 are all drug efflux pumps responsible for the extracellular transport of a variety of antineoplastic drugs.
Furthermore, we observed increased expression of FK506 binding protein 1A and 1B (FKBP1B, FKBP1B) and N a + / K + -transporting ATPase subunit α 3 (ATP2A2), encoding an ion-pump responsible for establishing and maintaining the electrochemical gradients at the plasma membrane of the cardiomyocyte.
V-ATPases are multisubunit proton pumps responsible for the acidification of intracellular compartments in eukaryotic cells.
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