A Medtronic pump (Paradigm or Veo; Medtronic, Minneapolis, MN) with insulin lispro or insulin aspart was used for all patients.
The basal insulin requirement in 35 type 1 diabetic patients without detectable C-peptide using the insulin pump (Paradigm 712) was investigated during 2 3 weeks of hospitalization.
The participant's pump was disconnected, and the study pump (Paradigm Veo; Medtronic Minimed) containing the subject's usual analog insulin, insulin aspart (NovoRapid; Novo Nordisk, Bagsvaerd, Denmark), or insulin lispro (Humalog; Eli Lilly, Indianapolis, IN), was attached.
On both study mornings, subcutaneous (SC) infusions of insulin lispro (IL) with the commonly used insulin pumps Paradigm 522 (MiniMed, Northridge, CA) and Accu-Chek Spirit (Roche Diagnostics, Mannheim, Germany) were established.
Daily insulin dosages were recorded from subcutaneous insulin pumps (MiniMed Paradigm MMT 770, Medtronic Inc., Minneapolis, MN [ n = 6] and Accu Chek Spirit, Roche Diagnostics, Basel, Switzerland [ n = 1]) and manual recording by one subject using a four times daily insulin injection regimen.
Five Animas 2020 pumps (IR1200/2020) and five Medtronic Paradigm pumps (1.8 mL cartridge) with 60-cm infusion systems were loaded with aspart insulin at sea level.
During a 1-month run-in phase, participants used a glucometer (Bayer Ascensia Contour Bayer Diabetes Caree, Basel, Switzerland) and an insulin pump system (MiniMed Paradigm REAL-Time System; Medtronic, Tolochenaz, Switzerland) able to integrate CGM in the study phase.
The MiniMed Paradigm 712 pump (Medtronic MiniMed Inc., Northridge, CA, USA) was used for CSII.
We used a Paradigm 712 pump (Medtronic, Northridge, CA) with which we program basal insulin infusion hourly every 0.05 units.
All patients used an insulin pump system (Mini-Med Paradigm REAL-Time System and Medtronic SofSensor; Medtronic, Tolochenaz, Switzerland) throughout the study.
was provided unless the participant was already using a Medtronic Paradigm insulin pump (Medtronic MiniMed, Inc., Northridge, CA), in which case a MiniMed MiniLink REAL-Time Transmitter (Medtronic MiniMed, Inc).
