Exact(5)
An i.v. pulsed administration has potential advantages over daily oral cyclophosphamide of reduced exposure, bladder protection and improved compliance.
This overall trend is superimposed by an oscillation resulting from the pulsed administration of IFN α, which is also distinctly visible on the level of stem cells.
For the range of combinations in (1) and (2), we address whether the continuous or pulsed administration of the drugs appears both safe and clinically beneficial.
The trial did not achieve its main objective to improve the non-progression rate at 8 weeks with the "pulsed" administration of erlotinib (80.3% GC-erlotinib vs 76.9% GC-placebo, P = 0.5143) and there were no significant differences in the RR between groups (35.5% GC-erlotinib vs 24.4% GC-placebo, P = 0.12).
Elisa R et al. [ 20] suggested that the efficacy of administering enrofloxacin at 10 mg/kg in medicated water to turkeys was evaluated by applying a PK/PD approach to the kinetic parameters obtained after oral pulsed administration and to the MIC values of avian pathogenic Escherichia coli (APEC) strains isolated from commercial turkey flocks.
Similar(55)
Intravenous but not vaginal administrations of bmDC pulsed in vitro with UV-inactivated HSV-2, or with purified HSV-2 envelope glycoproteins gave rise to complete protection against disease, as well as death caused by genital herpes infection.
We furthermore show that pulsed IFN α together with continuous TKI administration is the most promising strategy for a combination treatment in which the therapeutic benefit prevails adverse side effects.
Even in a less-favourable situation (i.e., IFN α does not induce activation of leukaemic stem cells), a pulsed IFN α therapy under continuing TKI administration shows no adverse effects compared with standard TKI monotherapy.
These results were based on the analysis of paired samples from only 6 patients, and this study had the confounding effect of the administration of a MART-126 35 MART-126 35sed DC vaccine in addition to tremelimumab.
The life altering essence that pulsed through my heart, Began to pulse through yours.
In transplantation, different approaches have been attempted to harness the therapeutic potential of such cells, including the administration of donor DCregs or recipients' DCregs pulsed with donor antigen prior to transplantation51,52.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com