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Due to this, the typical separation of cortical and medullar areas, the white and red pulp areas, and the germinal/peripheral centers where completely blurred or eliminated in the thymi, spleen and mesenteric lymph nodes, respectively (Figure 1C, compare upper and lower panels).
We therefore investigated whether development of the graft white pulp areas required adult lymphocyte-derived LTα.
In summary, ED15 LTα−/− grafts developed organized white pulp areas comparable to WT ED15 spleen grafts.
In human spleen, both receptor types are localised to T- and B-lymphocytes (pulp areas).
These cells were located within organized white pulp areas, which supported T-dependent immune responses.
Basically, pRBC are eliminated by phagocytes in the red pulp areas of the spleen, specifically in extravascular beds.
Similar(37)
The aim of this study was to determine possible changes in pulp cell density, pulp area, and dentinal thickness with age.
Histopathologically compared to the primary spleen and accessory spleens, splenic implants have a thinner capsule which is devoid of elastic tissue and the white pulp area or hilum is usually deficient [8].
In the present case, the excised splenic tissue had a firm capsule but did not present apparent hilum or white pulp area, and thus, we could not precisely diagnose as an accessory spleen or splenosis.
Histologic examination of Chk1+/− spleens using hematoxylin and eosin staining revealed a range of phenotypes from a mild expansion of red pulp area to an overwhelming disruption of splenic architecture.
Right quantification of red pulp area in WT and Vav1-P1cKO spleens.
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