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The relative order of pulmonary activity in terms of both oxygenation and compliance was given as: S-MB > MB > pig SP-B > SP-B(1 8)> lipids alone (negative control) (Figure 14).
As the S-MB peptide investigated here had even greater pulmonary activity than MB, S-MB may be preferred over MB in totally-synthetic surfactant preparations also containing synthetic lipids.
The pulmonary activity of S-MB and MB surfactant (described above) was investigated in comparison to native pig SP-B (positive control) and SP-B(1 8) surfactants and lipids alone (negative control) during a 90 min period following intratracheal instillation of these surfactants into ventilated rats with ARDS induced by in vivo lavage.
This method could be also useful to evaluate indirectly pulmonary activity of the CF disease.
The intensity of immunostaining was compared with the pulmonary activity of a P450IA1-dependent enzyme, aryl hydrocarbon hydroxylase (AHH), and with P450IA2-related metactivityctivity estimated from the ratio of caffeine metabolites in urine.
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The pulmonary activity-time curve of 99mTc-PulmoBind was integrated from appearance to peak.
The results demonstrated that SMPS showed potential effects on relieving lung injury and preventing oxidative stress, reflecting by decreasing the serum levels of C3, CRP and GGT, increasing the pulmonary activities of SOD, GSH-Px, CAT and T-AOC, as well as down-regulating the MDA and LPO contents, respectively.
Furthermore, rats chronically exposed to 100 ppm paraquat in the water had elevated pulmonary activities of glucose-6-phosphate dehydrogenase and GSH reductase.These results were consistent with the hypothesis that lipid peroxidation is involved in the toxicity of paraquat.
The system continuously monitors several cardio-pulmonary-activity variables, which allowed us to evaluate ventilatory strategies associated with coughing, which is one of its novel features.
The present study revealed that IL-8, IL-10, IL-18, TNF- α, and IP-10 are significantly correlated with pulmonary disease activity and global disease activity.
Specifically, we found a moderate correlation of S100A4 serum levels with the MYOACT score (r = 0.34; P = 0.001), constitutional (r = 0.30; P = 0.003), extramuscular (r = 0.36; P = 0.0001) and pulmonary disease activity (r = 0.43; P = 0.0001), but not with skeletal disease activity (r = 0.13; P =0.208).
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