For W631.29, F691.35, F761.42, F3326.65, Y3356.68 and E4288.66 values were calculated from the 25 ns S1,S2-DAT equilibration trajectory and the two intracellular pulling trajectories.
In addition, the Jarzynski's equality method can also be used to calculate the shape of one-dimensional free energy landscape [30], [59], but it needs a large number of pulling trajectories in order to reproduce the shape of free energy landscape accurately [60].
When the activity of ER terminates, (s_{mathrm {dynamic}}) increases, which pulls the trajectory through the curve of jump down knees (cyan) and hence switches KE to the silent phase.
The rise in (s_{mathrm {dynamic}}) pulls the trajectory across the curve of jump down knees of the (V_{mathit {KE}}) nullcline (dark blue), terminating the active phase of KE.
Nonetheless, they do constrain weights to ensure that (h_{mathit {KE}}) decays sufficiently during each active phase such that subsequent rises in (s_{mathrm {dynamic}}) can pull the trajectory across the curves of jump down knees, transitioning KE to the silent phase along with its interneuron partner, as desired.
The best candidates for necessary conditions for chaos still appear to be (1) WSD, which is rather weak, or (2) the presence of stretching and folding mechanisms ("pulls trajectories apart" in one dimension while "compressing them" in another).
Put it all together and you get the biggest challenge we face as a nation today -- a dangerously negative trajectory pulling us ever closer to the point of no return.
This type of control can be thought of as a spring, attached to the trajectory points, pulling the stylus' tip to the next point (Figure 1.a).
A migration trajectory is chosen and a small force pulling the ion along this trajectory added to the ion that is to hop.
In the middle phase, lateral movement and pulling consisted of two distinct trajectories with two peak velocities, which as efficiency increased, gradually merged into one smooth, continuous trajectory that minimized the time and energy required to obtain the reward (Fig. 3B).
