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Iplex, however, was thought to be more potent for treating A.L.S. Insmed agreed to pull its drug off the market.
On Thursday, this competition revealed some new problems, prompting Merck to pull its drug off the market, advancing medical practice and giving doctors important new ideas.
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In March Novartis pulled its drug for irritable bowel syndrome, Zelnorm ($561 million in sales), at the request of regulators after an analysis found a higher rate of heart attacks and strokes in patients who had taken the drug.
In October the FDA forced Abbott Laboratories to pull its antiobesity drug Meridia off the market owing to fears about cardiovascular side effects.
The world of anti-inflammatory drugs was turned upside down last year when Merck pulled its blockbuster drug Vioxx from the market after a study showed that Vioxx users were more prone to heart attacks and strokes.
The glare of bad publicity hit Merck & Co. in September when it pulled its anti-inflammatory drug Vioxx off the market because of an increased risk of heart attacks and strokes in patients.
In 2005, the company pulled its multiple sclerosis drug, Tysabri, from the market after a patient who was taking the drug in conjunction with another medication died of a rare brain disorder.
Regeneron, which went public in 1991, had its darkest time after it pulled its Lou Gehrig's disease drug.
As for COX-2, in late September, drug giant Merck pulled its COX-2 inhibitor Vioxx off the market after a study found that patients on Vioxx suffered more heart attacks.
The company is discussing with regulators in the United States and Japan whether to pull the drug from those markets, where it has been sold for more than 18 months.
The company did not pull the drug from shelves, however, or acknowledge that it was addictive.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com