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The GO and its annotations to gene products are now an integral part of functional analysis, and statistical tests using GO data are becoming routine for researchers to include when publishing functional information.
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This data portal provides tissue-specific expression patterns and co-expression networks, along with such previously published functional genomic data as protein domains, predicted isoform-level functions and functional relationships.
These in vitro and in vivo findings thus provide mechanistic evidence to support published functional studies that have shown that L-phe administration restores endothelial function and attenuates the observed hypertension induced by administration of the GCH1 inhibitor di-amino-hydroxypyrimidine (Mitchell et al., 2004).
The present data on Dlx3 and recently published functional studies show that this transcription factor may be instrumental during growth in the control of matrix deposition and biomineralization in the entire skeleton.
The hypergeometric distribution was used to determine if previously published functional categories of genes were significantly enriched in the comparisons.
Significantly, there is some correspondence between the phylogenetic groupings described above and published functional characteristics of KAP-β subfamily members.
An overview of the investigated Kv1-4 chandels and their published functional characteristics is given in Table S1.
It would however be problematic to reconcile published functional data for both proteins if their N-terminal domains were oriented toward the lumen of the TGN.
Second, none of the previously published functional studies were performed to evaluate the role of SPP1 in males and females separately.
These findings clearly demonstrate agonist promiscuity at least for TAAR4 which has also been shown for TAAR1 by previously published functional data [5], [6], [7].
The published functional data [7], including correlations between TCR signalling and carriage of the different alleles of Arg620Trp strongly supports that this non-synonymous SNP is the causal variant.
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