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This changed the direction of overall effect for that study compared to what was published in the previous meta-analysis [ 15] (See below).
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23 We restricted the search to only new papers that were published after the previous meta-analysis in 2006 (see appendix I on bmj.com).
The search identified an additional 7 trials (14 in total) since the previous meta-analysis.
Therefore in the present study we aimed to broaden the previous meta-analysis to include studies published since 2006 to confirm the association of IM and MS and to see if the relationship between IM and MS is latitude dependent.
Compared with the previous meta-analysis [ 38], another eight studies were included in this meta-analysis.
The Phase II trial had been included in a previous meta-analysis using published mean data [ 5].
In a previous meta-analysis based on published aggregate data 34 one studyw9 was excluded because it showed no data on variability of the results.
This observation had been suggested in a previous meta-analysis [73] but has been challenged by another recent meta-analysis [74].
Its association with PCOS was negative in a previous meta-analysis which had possible shortcomings.
The results of this meta-analysis are in contrast to those of a previous meta-analysis published in 2009.
This is an update of a previous meta-analysis published in 2005.
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