We would like to thank Mary Mauzy, Shinichiro Enomoto, and Mark Rutherford for providing additional pre-publication expression data for several C. parvum genes.
In order to examine whether PGP 9.5 is a marker of pathological angiogenesis, we also stained wild type lung sections where staining was found exclusively in large vessels but not in capillaries (Figure S6E) in line with a recent publication showing expression of PGP 9.5 in human carotid arteries [33].
In contrast to NGF, only one publication provided expression profiling data analysing gene sets regulated by IL-6 upon neuronal differentiation.
In a more recent publication, stable expression of specific splicing-derived E6*I, E6*II, or E6 in oropharyngeal SCC showed radiosensitivity for cells expressing E6*I and total E6 supporting a link with p53 pathway [ 44].
In June 2013, an integrity committee at the university concluded that data patterns in the studies were "practically impossible," and recommended the publication of "expressions of concern" in the journals involved.
Most publications report expression only in breast cancer and not in healthy controls.
In many publications, EMH expression was studied using tissue microarrays (TMAs) 72.
Next, spectral clustering was run on the gene set using GO, publications, gene expression, and all possible combinations of the individual sources.
Chado is designed for storage of complex relationships among data types such as sequence features (e.g. genes, mRNA, chromosome, etc)., controlled vocabularies such as ontologies, phenotypes, genotypes, phylogeny, stock collections, publications, gene expression data and more.
In a recent publication on EGFR expression in 236 cases of CC EGFR expression was a significant prognostic factor and also a risk factor for tumour recurrence in intrahepatic CC [ 23].
CHRDL1 interestingly is under-expressed in colorectal cancer (85) while over-expressed in pancreatic cancer (86) and for CA4 there is currently no publication associated with expression of these gene in cancers.
