Sentence examples for ptp it from inspiring English sources

While the phosphomimetic mutation again interfered with PTP, it did not produce an increased release probability, as measured by paired-pulse ratio.

Given that yeast EndoG is physically and functionally connected to the PTP, it appears plausible that α-synuclein toxicity is exerted via opening of the PTP and subsequential translocation of mitochondrial EndoG to the nucleus, causing DNA fragmentation and death.

To investigate the role of Munc18-1 in PTP, it was necessary to develop a gene replacement strategy in which endogenous Munc18-1 proteis is replaced with a PKC-insensitive mutant.

With the special structure of the decay slope, in order to find the conditions where DMT w/wo achieves PTP performance, it suffices to show the following: (A) the decay slope of side channel given sum multiplexing gain is larger than (d_{M,m_{mathrm {I}}}(r)) in their last admissible intervals, respectively, and (B) max(r sum)≥2m I.

On the basis of their locations in the PTP domain, it has been suggested that LS SHP2 mutations may harm SHP2 phosphatase activity.

In further accord with a role in PTP regulation, it was reported that TRAP1, and also the mitochondrial pools of Hsp90 and Hsp60, interact with CyP-D and prevent its ability to induce the pore in tumor cell models [50,51].

As for hepatic PTP activity, it showed positive correlation with serum glucose level (0.702, P < 0.01) and HOMA-IR index (0.538, P < 0.01), while it showed negative correlation with serum adiponectin level (−0.515, P < 0.01) and hepatic GSH content (−0.756, P < 0.01).

It seems that there is substrate specificity in the dephosphorylation of STATs by PTPs, and it is not clear how this specificity is achieved.

As concerning the interaction of the L12 loop from ERK2 with KNRY motif of PTP-SL it confirms a former hypothesis that the ERK2 catalyzed phosphorylation and the PTP-SL catalyzed dephosphorylation require different conformations of the complex [14].

In a study where similar proline-rich substrate-binding motifs were deleted in the carboxyl terminus of PTP-PEST, it was demonstrated that some of these motifs are required in order for the phosphatase to be able to inhibit B-cell activation [ 25].

PF3D7_1127000 have incomplete PTP motif and it probably does not contain any catalytic active region for protein phosphatase activity.