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Their interpretation remains to be further studied, thus the prediction model was based solely on PSA trends.
However, it remains to be validated to what extent the doubling trends are established by the end of the first year, and for this purpose more intensive coverage of PSA trends would be already required for the early follow-up.
The major PSA trends were effectively captured readily by linear components in the model based on the optimality of high values of the smoothing parameter λ (Fig. 1c) as well as upon visual inspection (Fig. 1d f; Fig. 2a,b).
To decrease the chance of detecting 'noise' (or common fluctuations of serum PSA levels), we assessed not absolute PSA but PSA trends.
Similar(56)
Using age-period-cohort modelling, the number of cases expected in 1991 2000, based on pre-PSA trends, 1971 1990, was compared with that observed.
In this study, clinicians showed patients their PSA-related trends via the charts, as shown in Figure 4 and explained to them the predicted potential disease risk which was presented to them in a table, as shown in Figure 5. Thus, the clinician could refer to the interactive guideline in Figure 6 while offering the suggestions, ordering the proper treatment, and tracking the follow-up conditions.
For low PSAs, trigger PSA remains most relevant.
The IL23R SNP showed significant association in the PsA subtype (P trend = 0.04).
The IL23R SNP showed significant association in the PsA subtype and a trend towards association in the ERA subtype, with similar effect sizes in both subtypes, suggesting that the lack of significant association in the ERA subtype of JIA may just be due to a lack of power (this subtype had 37% power to detect an association).
Longitudinal trends of u-PSA did not display major discrepancies from those of t-PSA.
Furthermore, even in the PSA era, we observed a trend similar to the age-specific incidence of disease found in the pre-PSA data (Table 3).
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