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It should be noted that the patients in this cohort were recruited in the pre-PSA era, and thus PSA data were not available.
The available original tissue blocks were now sectioned and stained for PSA (n = 347), as earlier described, resulting in combined Ki67 and PSA data in 332 cases.
Data was collected retrospectively from Turku University Hospital's medical records and PSA data was obtained from Turku University Hospital laboratory data sources.
Meta-analysis of all psoriasis and PsA data from Immunochip and combined validation data sets exceeded genome-wide significance (P=3.05 × 10−8; Supplementary Fig. 5).
In this work, we generated a complete Monte Carlo simulated PET study involving two groups of scans, in between which a biological phenomenon was inferred (a 30% decrease of Bavail), and used it in order to design an optimal data processing chain for the parameter estimation from PSA data.
b Particle size analysis (PSA) data of the same representative sample.
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Furthermore, even in the PSA era, we observed a trend similar to the age-specific incidence of disease found in the pre-PSA data (Table 3).
The pre-PSA data for the SW and NC zones showed the highest crude and age-standardized rates, but were surpassed by the SS zonal studies in the PSA period.
Selected loci were phased and imputed using the PsA Immunochip data set and, for the 5q31 locus, the WTCCC2 psoriasis data set.
Extracts of muscles from the heterozygous mice showed an approximately 50% reduction in PSA activity (data not shown).
However, we found the association to rs22476601 in the PsA Immunochip data was unaffected by the inclusion of the RA-GRS (p=1.29×10−5 vs PGRS=1.30×10−5).
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