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With the exception of true emergencies (eg, cauda equina syndrome), lumbar discectomy is usually performed as an elective procedure after a prudent trial of nonoperative treatment.
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In a subsequent interview, Clarke suggested that while it is sometimes prudent to move a trial away from where the alleged crime took place, in this instance it helped that Smith was tried by South Carolinians.
Morse's operator at the Baltimore end of the line telegraphed that emotions were so high among the public that it might be prudent to suspend the trial until things calmed down.
However, given the limitations of the existing methods, a close monitoring of HIV prevalence and incidence rates during the trial seems prudent.
These observations suggest that it may be prudent to consider clinical trials of novel therapies earlier in the course of glomerular disease with persistent proteinuria.
Hence, monitoring of pancreatic function and pancreatic disease in humans treated with GLP-1R agonists and DPP-4i in ongoing long-term prospective controlled clinical trials seems prudent.
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Besides intervention trials it seems prudent to develop new methodologies of feasible independent measures of individual exposure to psychosocial strain.
A moratorium on the use of etomidate in critically ill patients outside clinical trials may be prudent until its safety is established.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com