Altogether, our findings again reminded us that it is prudent to consider formulations as a potential source for chemical modifications and product heterogeneity.
Altogether, our findings again remind us that it is prudent to carefully consider formulation excipients as a potential source for chemical modifications.
In those patients with risks for NSAID toxicity, avoiding potent drugs with a long half-life or extended-release formulations is prudent.
Ultimately it is the adoption and merging of the different formulation technologies and prudent scientific validation that will dictate the future success of nutraceuticals.
Thus, while the consequences of such extensive possible cross-reactive immunity are hypothetical, we propose, for vaccine formulation, that it is prudent to select conserved sequences that are specific to the pathogen, and thus representative of a minimal number of variant sequences.
Prudent health policy seeks to encourage development of additional antibiotic formulations and mechanisms, even as financial pressures make this goal less attractive to industry.
However, if the commercialization strategy is to license the formulation to others for manufacturing and sales, it may be prudent, and at times necessary, to file for a patent as the licensees may request that applications be filed for protection.
A thorough investigation using multiple experimental methods is prudent before assigning a BCS classification, to avoid misjudgment in various settings, e.g., drug discovery, formulation design, drug development and regulation.
When developing a new drug product, it is prudent to plan for dissolution documentation during all phases of drug development so that if a change is needed in formulation, manufacturing process, equipment, or manufacturing site, dissolution profiles and f2 data can be used in lieu of the need to conduct PK/clinical trials.
