Sentence examples for prpc it from inspiring English sources

It replicates by corrupting any PrPc it encounters, twisting it into a new PrPSc, which in turn transforms more PrPc.

In light of our findings, albeit α2M was not found to directly interact with PrPC, it cannot be ruled out that α2M activity could play a role also in prion diseases and other neurodegenerative disorders in addition to AD.

Since the discovery that PTA selectively promotes precipitation of PrPSc over PrPC, it has been widely used to isolate PrPSc from various tissues of prion-infected animals.

This finding is quite interesting considering that interaction with flotillins has been suggested to have a role in the physiological function of PrPC; it can lead to activation of ERK (extracellular-signal-regulated kinase) 1/2 upon PrPC capping in T-cells [ 43], and can trigger the formation of Ca2+-independent PrPC-mediated cell adhesions in S2 cells [ 44].

The NMR structure of the horse (Equus caballus) cellular prion protein at 25 °C exhibits the typical PrPC [cellular form of prion protein (PrP)] global architecture, but in contrast to most other mammalian PrPCs, it contains a well-structured loop connecting the β2 strand with the α2 helix.

The fundamental event in prion diseases seems to be a conformational change in cellular prion protein (PrPC) whereby it is converted into the pathologic isoform PrPSc.

Subsequently, all 55 clones were screened for binding to native PrPC as it is displayed on the cell surface (Supplementary Figure S2).

This domain adopts a globular and α-helix rich fold in PrPC whereas it is largely aggregated and β-sheet rich in PrPSc [4], [5].

The infectious agent of these diseases is thought to be an abnormally folded isoform (PrPSc) of the cellular prion protein (PrPC) and it is further thought that the accumulation of the misfolded prion protein leads to disease [1].

Although V14 also detected the di-glycosylated sheep PrPC but it did not detect the di-glycosylated sheep PrPSc.

Alternatively if a TSE agent is propagated on a non-homologous PrPC substrate, it may adopt more than one conformation, giving rise to different strains.