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For patients in the untreated depression cohort, each patient was assigned a proxy "treatment discontinuation" date corresponding to the date of treatment discontinuation of their matched duloxetine comparator.
The proxy treatment duration of 2.5 months has been used for both drugs, according to the pivotal trials' median progression-free survival outcomes shown in Table 1.
This observation suggests substantial confounding by indication, where use within the first month could be a proxy (treatment) for early manifestations of gout, although a true association cannot be ruled out entirely.
Key inclusion criteria common to the four registries were: all adult patients with a diagnosis of NV-AMD willing and able to provide informed consent personally or by legal proxy; treatment with ranibizumab according to local practices and protocols, and within the local licensed indication of ranibizumab.
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In the cohorts that included patients in periods with different treatments strategies (EAC, Umeå and Groningen) an additional adjustment was made for the inclusion period (as proxy for treatment strategy) as radiographic joint damage varied between different inclusion periods.
Given that the medical community sometimes considers follow-up appointments a proxy for treatment failure or misdiagnosis, the results are encouraging.
Failure to pick up drugs on time serves as a proxy for treatment interruption and suboptimal drug concentrations, which are associated with virologic failure and the evolution of drug resistance [11], [12], [13].
All analyses were adjusted for age, gender, and inclusion period (as proxy for treatment strategy).
The analysis was adjusted for age, gender, and inclusion period (as proxy for treatment strategy).
Analyses were adjusted for age, gender and different inclusion periods as proxy for treatment strategy [ 15].
Median progression free survival has been used as a proxy for treatment duration due to the availability of data.
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