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Exposure was determined by examining the proxy date of the elapsed day's supply with a 31-day grace period.
To reduce this bias, each person in the unexposed group was given a proxy date of prior infection achieved by randomly assigning the exposure dates observed in the exposed group to nonexposed persons.
For those cases in which the real date of onset of symptoms was unknown, a proxy date of onset was estimated by subtracting two days (average of days between date of onset and date of laboratory testing in those cases in which both real dates were known) from the date of laboratory testing.
For each person, the follow-up time, or time at risk for sequelae (years, or part thereof) was enumerated from the date of prior infection, or proxy date of prior infection for unexposed persons, to admission date for the sequelae of interest, date of death, or December 31, 2007 (end of follow-up), as appropriate.
Similar(56)
The various intervals of time used for the estimation showed important variations among health regions, as presented in Additional file 1: Proxy dates for estimating date of onset.
If this date was missing, an estimation was performed using a "proxy date" based on the first of the following dates with a non-missing value: date of sample collection, date of physician notification, date of laboratory notification, date of reception of physician report by authorities, and/or date of reception of laboratory report by authorities.
When date of onset had to be estimated, the median time period (in days, by health region) between the onset and proxy date was subtracted from a case's specific proxy date and used as the estimated date of onset.
Date of hospitalization was used as a proxy for date of illness.
Follow-up was measured from a proxy interview date of July 1 in each of these years until the end of June 2011.
By law, she said, the proxy dated closest to the date of the election is the only one that counts.
The earliest HIV-diagnosis date from either study was used unless one date was either 1st January or 30th June (proxy dates used when only year of diagnosis is known/reported) and the later date was during the same year, in which case the later date was used (n = 116).
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