Sentence examples for proximal steps from inspiring English sources

Finally, promising novel treatment modalities for laminopathies, such as farnesyl transferase inhibition and gene-based therapies, might help not only to illuminate mechanisms that link genotype to phenotype, but also to provide hope for patients suffering with laminopathies, since these treatments are designed to modulate key early or proximal steps in the pathogenesis of these disorders.

One of the proximal steps in intracellular TGFβ signal transduction is the phosphorylation of SMADs 2 and 3.

At the same time, it is not clear how lysosomal disintegration is linked to the proximal steps of NLRP3 activation.

Despite the above-mentioned mechanisms that were reported to trigger NLRP3 inflammasome formation, especially the proximal steps in NLRP3 activation are not well understood.

Repair and replacement of damaged mitochondria are probably controlled at a transcriptional level, but proximal steps in the signalling pathway still need to be elucidated.

Our overall inference strategy is to use gradient descent on the likelihood combined with proximal steps on each of the regularization terms.

Now, we are going to build the dual interior proximal step for solving (GVI).

The dual interior proximal step at the iteration is generated by using the following scheme: (3.1).

In the first algorithm, two projections on feasible set and a projected subgradient step followed by a proximal step is need to be computed per each iteration.

Proximal gradient methods are among the methods used for solving problem (1), which allow to decouple the contribution of the functions f and g in a gradient descent step determined by f and in a proximal step induced by g [7, 8].

Step 2. (Proximal step) Find { z n } such that F ( z n, y ) + 〈 A u n, y − z n 〉 + 1 λ n 〈 y − z n, z n − u n 〉 ≥ 0, ∀ y ∈ C, where { λ n } ⊂ ( 0, ∞ ) is a real number sequence.