Sentence examples for proximal regulator from inspiring English sources
Despite the fact that BDNF mRNA was increased only after 14 days of fluoxetine treatment, blocking its action at a time when there was no discernible change in BDNF mRNA prevented not only the expected increase in progenitor mitosis, but also that in pCREB, presumably a more proximal regulator of neurogenesis.
The proximal regulator of Nrf2 is Keap1 (Kelch-like ECH-associated protein-1), a cysteine (Cys -rich protein that normally interaCys -richiently with Nrf2, targeting it for degradation.
At the same time, the complexity and apparent redundancy of p27 regulatory pathways raises doubts as to whether targeting a single enzyme or proximal regulator can lead to sustained p27 accumulation in tumour cells.
6) It is unclear why data on Aurora-A kinase are not shown, even though this kinase is known to be a proximal regulator of ciliary assembly that is localized to the basal body and targeted by the APC.
Nonetheless, substantial effort has been directed toward elucidating the proximal regulators of mammalian Hippo signaling in recent years and significant progress has been made on this front.
Finally, our results provide some confirmation that the idea that p70S6K and 4E-BP1 are important proximal regulators muscle protein synthesis.
Focal adhesion kinase is important receptor-proximal regulator of cell shape, adhesion, and cell motility.
A known receptor-proximal regulator of TNF- and Fas-induced apoptosis is the cellular FLICE inhibitory protein (cFLIP).
The present chapter critically reviews the development in these three avenues of research with a special emphasis on the two "top secrets" of the TOP mRNA family: the scope of its members and the identity of the proximal cellular regulator(s).
Our model revealed a strong influence of the receptor proximal negative regulator (SHP-1 in this case), which generally balances against positive signals to ensure system homeostasis [ 51].
Moreover, alterations in macrophage sensitivity through defects in membrane-proximal negative regulators have already been linked directly to disease.
