Sentence examples for proximal regulation from inspiring English sources

Due to the proximal regulation, the overall amino acid level often changes in parallel to those of sugars.

As alefacept targets T cells, it is tempting to speculate that in the skin, T cells are involved in the proximal regulation of IL-20.

JUNB is a prototypical gene model for the promoter proximal regulation of immediate early genes, and it is rapidly induced in response to serum.

Significantly, these sites directly overlap with the integration sites produced by NELF and SPT5, suggesting that Integrator plays a role in promoter proximal regulation of these genes by NELF and DSIF.

The distance between VPA DHSSs and expressed TSS clusters is usually from 10 kbp up to several Mbp long (Fig.  3f), indicating that the induced DHSSs are not mainly involved in proximal regulation of transcription.

(NELF and DSIF regulate a large percentage of genes (∼30%) through promoter proximal sites, including both constitutive and inducible genes, but promoter proximal regulation has been studied predominantly at inducible genes).

These results suggest that non-induced DHSSs may be involved in proximal, positive regulation of non-induced as well as induced TSS clusters, whereas the induced DHSS may represent mainly distal regulation or repression.

We do not dispute that USF may play an important role in APP proximal protein regulation but investigate the possibility that other factors and cofactors also operate on this sequence.

Even though our method could separate periodical genes from non-periodical ones with fair accuracy, cell cycle progression control is a much more complex system than could be simply explained by proximal transcription regulation alone.

Our results strongly suggest that many obesity-associated SNPs are associated with proximal gene regulation, which was reflected by association of obesity risk allele genotypes with differential DNA methylation.

In eukaryotes, Spt4/5 is involved in mRNA 5′-capping (Wen and Shatkin, 1999), promoter-proximal gene regulation by the negative elongation factor NELF (Palangat et al, 2005), transcription-coupled DNA repair (Jansen et al, 2000), organism development (Guo et al, 2000), and recruitment of activation-induced cytidine deaminase to DNA during antibody diversification (Pavri et al, 2010).