As the intercellular coupling driven by neuropeptides synchronizes intracellular molecular clockworks of individual neurons (Maywood et al., 2006, 2011; Liu et al., 2007), misregulation of these neuropeptides will provoke disruptions in circadian parameters.
Catalytic events (e.g. economic crisis) provoke disruptions in the policy equilibrium and can lead policy makers and politicians to pay greater attention to the problems highlighted by these events and can trigger convergence between problems, policies and politics [ 15, 16].
A miners' strike provoked disruption to electricity supplies and the nation was put briefly on a three-day week.
It combines market analysis with business model innovation and directed system evolution, together with a proposition of ten inventive vectors for provoking disruption of existent technologies in the market.
Small-angle X-ray scattering reveals that C-60 provokes disruptions of external membranes of multilamellar vesicles only after freeze and thaw cycles.
"One of the many aims of terrorists with an attack is to provoke a disruption of that society.
AMPs provoke the disruption of the bacterial membrane to kill the bacteria.
Antagonistic epistasis indicates that the effects of the first mutation at a nucleotide site provoke a disruption of the structure that is more severe than the one provoked by the effects of a second mutation at another site [ 29].
In conclusion, we postulate that genetic and epigenetic variation, together with environmental factors that shape expression and methylation patterns, can affect different levels of the NFκB pathway and provoke the disruption of the tight regulatory equilibrium that ensures its optimal control of the immune response.
The biological basis for the structural effect of PNE is still largely unknown; the early response may be due to both the mechanical and biochemical effects of PNE which provoke tenocyte disruption, as well as local inflammatory processes occurring in the soft tissue which enable phagocytosis and repair of the affected tissue.
Furthermore, elimination of B cells by anti-CD20 antibodies from the synovial tissue provokes a disruption of T-cell activation and provokes the production of proinflammatory monokines [ 6], proving an important role of B cells in the pathogenesis of RA.
