Our present findings imply that WA by promoting ROS provokes accumulation of NQO1, which inhibits 20S proteasome and stabilizes TAp73.
14– 16 Within the animal, Bim loss provokes accumulation of hematopoietic cells, particularly lymphocytes, impairs deletion of autoreactive thymocytes 17 and B cells, 18 and is required for shut-down of T cell immune responses.
Lysosomes can be disrupted by chloroquine or bafilomycin A to block autophagosome degradation and provoke autophagosome accumulation, which is marked by an increase in LC3-II [7].
In addition to palmitate, we introduced oleate, a less problematic free fatty acid to provoke lipid accumulation.
According to this theory, free radicals, essentially Reactive Oxygen Species (ROS) which are produced as by-products during normal metabolism inside mitochondria provoke the accumulation of oxidative damage.
Thus, to provoke lipid accumulation we used easily incorporated free fatty acids, which are both esterified to triglycerides and cholesterol ester.
Treatments with stimuli such as Bone Morphogenic Protein 7 (BMP7) and cAMP, that induce neuronal-like differentiation, provoke nuclear accumulation of FGF2 and FGFR1 in various cell lines in culture.
TBI may not only provoke the accumulation of hyperphosphorylated tau protein, as CTE, but also of Aβ, α-synuclein, and TDP-43, possibly increasing the likelihood of developing AD, PD, and motor neuron disease.
In the AL condition, continuous glycolytic throughput would tend to provoke an accumulation of NADH and lower NAD availability, whereas the CR- and IF-induced fasting would decrease glycolytic NAD demand and increase NADH oxidation and NAD regeneration.
Results indicated that 4d and C14G1 compounds provoked preferential accumulation of JC-1 monomers (green), an indicator of mitochondrial depolarization, and interfered with the formation of JC-1 aggregates (red) (Figure 2).
