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Methacholine bronchial provocation tests were performed and bronchial responsiveness defined when the provocative dose to decrease by 20% the forced expiratory flow volume in 1 sec was ≤ 1 mg cumulative dose of methacholine.
We measured the provocative dose of methacholine producing a 20% fall in FEV1 (methacholine PD20) as the primary outcome, with secondary outcomes being lung function, surrogate inflammatory markers, diary card responses, quality of life, and safety.
To evaluate the laboratory test or set of tests (ie, symptoms, exposure, and sensitization to the allergen, and the provocative dose of methacholine [Mth] causing a 20% fall in FEV1 [PD20] and the maximal response plateau [MRP] to Mth) that best identifies a case of mild asthma.
Adinoff et al [ 24] reported a mean provocative dose of 3.0 mg/ml Methacholine in their preschool children and infants.
The results are expressed as the provocative dose of methacholine to cause a 20% fall in FEV1 (PD20).
AHR to methacholine was defined as a provocative dose causing a 20% fall in FEV1 of 1814 μg or less, AMP as a provocative dose causing a 20% fall in FEV1 of 50.5 mg or less and mannitol as a provocative dose causing a 15% fall in FEV1 of 635 mg or less.
Similar(43)
PDs (provocative doses) of MCh to achieve a certain increase in RL were significantly lower after LPS administration.
PDs (provocative doses) were defined as the dose of MCh required to alter an individual lung-function parameter to a certain percentage level above or below baseline value.
The provocative cumulated dose of delivered cold nebulized water producing a 20% fall in FEV1 (PD20 UNCDW) was calculated by linear interpolation on the dose-response curve.
The provocation proved provocative.
A dose-control system allows administration of defined doses of pharmacological or provocative aerosols during measurement [ 16].
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