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Thirty patients with migraine without aura (22F, 8 M) completed both days of the provocation study.
One provocation study has also examined the incidence of premonitory symptoms induced by intravenous PACAP38 administration in MO patients [49].
In relation to this, one provocation study [88] found no relation between headache frequencies in MO patients and GTN-induced headache.
The patients responded well and thus the lack of sumatriptan response in the provocation study could not be explained by insensitivity of the study population.
The 15 patients, who subsequently treated their spontaneous attacks in a double-blind fashion, did so at least one month after the provocation study.
In this nasal provocation study, a common antihistamine approved for the treatment of seasonal allergic rhinitis was tested against placebo for evidence of additional properties.
Similar(43)
In both provocation studies [33, 40], no sumatriptan effect was found on the MCA circumference.
The same need exists for PACAP38 provocation studies in cluster headache and tension-type headache patients.
Emotion provocation studies in healthy volunteers have produced variable results, due to differences in experimental paradigm and instructions.
PACAP38 provocation studies have demonstrated neuronal and vascular changes taking place in the brains of migraine sufferers both ictally and interictally.
In a total of three PACAP38 provocation studies, 46 out of 66 (70%) MO patients experienced migraine-like attacks (Fig. 1).
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