In phase 3, the provisional item list was pre-tested in 52 patients in four languages and this resulted in a 21-item module.
All analyses of the WE-CARE validation were based on assessments at Week 0, except for test-retest reliability, which incorporated assessments at Week 0 and Week 2. Initial factor analyses for item reduction were conducted with the aim of establishing which of the provisional 68 items in WE-CARE belonged to domains or conceptual areas and which items should be retained.
Moreover, a first factor analysis established which of the provisional RTQ items belonged to dimensions and should be retained.
This group encoded the first version of RTQ, comprised of the provisional 85 items on a five to six-point ordinal scale, according to two reference time periods : during the previous 4 weeks, or since transplantation.
The result was a provisional 21-item instrument comprising 2 parts: a descriptive part (11 items), which included questions about resources devoted to treatment, and a scale part (10 items), which included questions about treatment burden and overall satisfaction.
1. Conference of the Parties to the WHO Framework Conventionon Tobacco Control Sixth session: Provisional agenda item 4.4.2 Moscow, Russian Federation,13-18 ,13-18 October 2014
However, in some cases the provisional diagnosis item "delirium, dementia and amnesic and other cognitive disorders" may be checked off to identify a diagnosis other than dementia, which might inflate the prevalence estimate of dementia.
Lin's concordance for the provisional QUAD 17 items was ρc = 0.81 indicating substantial test-retest reliability [ 37].
The Cronbach's alpha value for the 17 item provisional QUAD scale was 0.86 indicating good internal consistency.
Following the psychometric evaluation of the 17 item provisional QUAD, the research team considered these findings in order to finalise the QUAD.
