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Still, with a little patience, there are enough mosquitoes with bite to be found in the swarm, providing optimism that the rhinoceros may yet be toppled.
Attempts at restoring vision in dogs and human by gene therapy have been made, providing optimism regarding potential for recovery of functional vision [ 36- 41].
However, unlike gene KOs, pharmacological agents only reduce but rarely completely ablate the activity of their targets, providing optimism that a NOD1 inhibitor strategy could be safe.
The past decade has seen a veritable explosion of studies revealing potential mechanisms through which migraine may be generated, providing optimism that the discovery of new medicines will be possible.
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At least Castonzo can provide optimism.
But birdies at No. 13 and No. 16 that pulled Woods from five over par to three over par provided optimism.
For Wales there were encouraging signs and the performance will have provided optimism that the co-hosts can advance from Group D if they can produce similar displays against the Cook Islands and USA.
Zaitoun said she wanted to give refugees "something of their own and provide optimism, an escape from reality and an explanation of their situation, as well as giving their parents some relief".
These developments provide optimism for the development of alternative and/or complementary strategies to lower renal sympathetic nerve activity.
Over the past 5 years, many efforts to develop drugs that target the RAS-RAF-MEK-ERK (MAPK) pathway have resulted in enhanced understanding of the KRAS mutant NSCLC and have provided optimism that this disease can be targeted.
Another geneticist, Seymour Benzer of the California Institute of Technology in Pasadena, is even more enthusiastic: "This [gene] provides optimism that it may, indeed, be possible to manipulate active life-span beyond the constraints that ordinarily apply in natural evolution".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com