Sentence examples for providing compounds from inspiring English sources

Moreover, a new series of NAMs was synthesized and tested, providing compounds with nanomolar affinity.

In the United States, Mayer counts a dozen universities -- including the universities of Texas, Kansas, and Kentucky -- that "are interested in providing compounds for industry and taking that compound even into clinical studies if they can".

At the same time, scaffolds derived from natural products may have a distinct advantage over non-natural cores in terms of providing compounds endowed with biological activities and should be used extensively in screening library design.

The evaluation of the library shows that new, non-natural compounds with relevant biological activity and improved physicochemical properties can be generated from the natural product indirubin, providing compounds that may be useful for kinase inhibitor drug discovery.

Utilizing the known compound 6a as a starting template and guided by computational tools to derive physicochemical properties known to be important for CNS permeable drugs, the design and synthesis of a small series of novel triarylacrylonitrile analogues have been carried out providing compounds with enhanced potency and selectivity for PKC over the estrogen receptor relative to tamoxifen.

The mixture was purified by silica gel column chromatography (eluent: PE-EtOAc, 10 1 5:1), providing compounds 10 (0.12 g, 21%) and 11 (0.32 g, 51%) as a white solid and a yellow oil, respectively.

The median toxic dose (TD50) was 500 mg/kg, providing compound 15 with a protective index (TD50/ED50) of 7.15 in the MES test.

After some optimisation, aldehyde 80 was synthesised using Parikh Doering conditions, 51 with subsequent Ramirez dibromoolefination 52 providing compound 81 in 89 % yield over two steps.

Soil fertility is the quality of a soil that enables it to provide compounds in adequate amounts and proper balance to promote growth of plants when other factors (such as light, moisture, temperature, and soil structure) are favourable.

Further optimization using parallel synthesis provided compounds with Ki's <50 nM.

Disulfide-rich neurotoxins from venomous animals continue to provide compounds with therapeutic potential.