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The asymmetry of the complex is a feature not incorporated in previous structural models and potentially provides the first view of an asymmetric reaction intermediate.
Our data provides the first view of the Hsp60 chaperone interaction network of a dimorphic organism.
The structure provides the first view of the intact C-terminus of a DRF, revealing the relationship of the DAD to the FH2 domain.
In summary, our genomic identification of Rbf1 targets in the Drosophila embryo provides the first view of this important class of corepressor in a whole animal; we find that in addition to a core of conserved genes related to RB protein function in cell cycle and DNA replication, the Rbf1 occupied genes are distributed among a diversity of functions.
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The emotional barrage is softened slightly by a light at the end of the corridor, providing the first view of an eternal flame, commemorating Holocaust victims.
Furthermore, they provided the first view of heterotetrameric NMDAR ion channels, and this illuminated the similarities with and differences from non-NMDARs, thus raising a mechanistic distinction between the two groups of iGluRs.
Importantly, a structure of an agonist-ligated β2 adrenoceptor complexed with its cognate G protein has provided the first view of a ternary complex representing the transition state in agonist-mediated G protein activation.
Nucleotide affinities in both subunits were determined by fluorescence correlation spectroscopy, indicating a weaker binding of nucleotide analogues to subunit B than to A. In addition, the nucleotide-free crystal structure of subunit B is presented at 1.5 Å resolution, providing the first view of the so-called non-catalytic subunit of the A1AO ATP synthase.
Here we provide the first view of a relatively complete rebbachisaurid skull and skeleton pertaining to the African species Nigersaurus taqueti (Text S1, Figure S1, S2).
Here, we provide the first view of the molecular basis of compromised HDAC8 function in human developmental disorders.
Our studies provide the first view of age-associated alteration of TCR-inducible gene expression in human CD4+ T cells.
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